The specialized supplement to stimulate the renewal metabolism of the joint cartilage
Like all human tissue, the cartilage constantly renews itself and Hyalgen can stimulate the cartilage regeneration process with a combination of molecules that enhance each other's action. Hyalgen can increases the synovial viscosity and can strongly assists the cartilage renewal metabolism. It can significantly improve the appearance of the joint cartilage structure in 12 to 24 weeks*. Hyalgen is clinically proven to support the growth of new cartilage tissue and can turn back the clock for your damaged joints.
(*) The sooner the joint condition is taken care of, the faster and the better the results will be.
Daily serving size: 10 gr / Servings per container: 21
Free from artificial sweetners, colors and preservatives. Sugar free.
Caution: Pregnant or nursing mothers, children under 18 and those with a medical condition should consult a health care professional before using this product.
Bioactive Collagen HP-BCP
The most effective form of collagen for acting cartilage renewal
Collagen is the main component of the joint cartilage, accounting for 65% of its structure. The cartilage itself contains specific cells, the chondrocytes, whose function is to manufacture the building blocks of its matrix, and we observe that these cells increase the synthesis of collagen when they are in contact with certain forms of collagen molecules.
Overall, the usefulness of oral collagen in improving joint health has been demonstrated in various clinical trials, but the high potency Bioactive Collagen Peptides (HP-BCP) have greatly increased its effectiveness. Taken orally it is better assimilated and it concentrates in the joints where it stimulates cell metabolism in the joint cartilage. It increases the biosynthesis of collagen and proteoglycans, which together account for 95% of the cartilage. These two components are responsible for the elasticity and stability of the joint complex.
The efficacy of HP-BCP has been confirmed in international clinical studies conducted by independent and renowned research institutes, such as the Collagen Research Institute in Kiel, Germany, Penn State University, Harvard University, and Tufts Medical Center in Boston. It can boost the natural regeneration process of cartilage tissue.
CLINICAL STUDY 1
COLLAGEN RESEARCH INSTITUTE
A study by the Collagen Research Institute in Kiel, Germany, showed that HP-BCP accumulates in joint tissue and stimulates cell biosynthesis to produce collagen and proteoglycans.
After 3 months, a significant change in formerly degraded cartilage is visible. The joint cartilage seems more supple, smoother and fuller in appearance.
Orally administered collagen hydrolysate halts the progression of osteoarthritis in STR/ort MICE. Oesser S et al.(2007) Osteoarthritis Cartilage 15:C61-C62,94
CLINICAL STUDY 2
TUFTS MEDICAL CENTER & HARVARD MEDICAL SCHOOL
Boston, MA (USA)
The study conducted at Tufts Medical Center and Harvard Medical School and presented at the OARSI congress (Osteoarthritis Research Society International) showed that oral intake of HP-BCP can provide improvement in human cartilage, for the first time measured using MRI (Magnetic Resonance Imaging) technology.
Change in knee osteoarthritis cartilage detected by delayed gadolinium enhanced magnetic resonance imaging following treatment with collagen hydrolysate: a pilot randomized controlled trial. McAlindon and Al. (2011) Osteoarthritis and Cartilage Volume 19, Issue 4, April 2011, Pages 399-405
Hyaluronic Acid Complex HJ
The joint capsule is filled with the synovial fluid, a thick substance that allows joint flexibility without friction. And what gives this fluid its remarkable lubricating property is Hyaluronic Acid (HA), a molecule that is capable of holding a huge amount of water, forming a cushion that helps the cartilage surfaces moving freely without rubbing on each other.
Joints affected with arthritis have a reduced concentration of HA and one of the steps towards improving joint health is restoring the viscoelastic property of the synovial fluid. The Hyaluronic Complex HJ™ is a unique patented natural ingredient with a very high content of sodium hyaluronate of High molecular weight.
Low Molecular Weight Hyaluronic Acid (LMW-HA) was sometimes thought a better alternative because its gut absorption is higher, but research shows that HA is only helpful and safe when it is of High Molecular Weight (HMW-HA). Indeed studies indicate that LMW-HA can be unhealthy since it promotes inflammation and also has side effets. However HMW-HA absorption has been evaluated and it is significant enough to reach the joint areas and HMW-HA is much more powerful at doing what HA does best, holding water.
Providing quality HA can increase joint lubrication, modulate inflammation and protect the cartilage.
When it comes to joint discomfort and joint health MSM can be very helpful, even for severe cases. MSM is a bioavailable natural form of organic sulfur found in all living organisms. It is exceptionally well tolerated, it is rated as one of the least toxic substances in biology, close to water. Sulfur is necessary for making collagen, the primary constituent of cartilage and connective tissue.
Sulfur is the third most abundant mineral in your body, after calcium and phosphorous, and yet it is often called the forgotten mineral. It has been neglected because of the widespread assumption that a person's sulfur requirement was met with adequate protein intake, providing the amino acids methionine and cysteine, but disfunctions in methionine metabolism could induce sulfur deficiencies. Nevertheless, scientists have observed that the sulfur content of cartilage decreases with age, and that this decrease parallels degeneration in the joints. A study has clearly shown that arthritic joints have sulfur levels three times lower than healthy ones.
MSM supplementation significantly help with joint problems for most people, without any side effects and MSM daily intake can be substantial, up to several grams. Aside from its anti-inflammatory action MSM can also support the immune system and improve the internal production of Glutathione, the body's major own antioxidant.
Eggshell Membrane NEM®
Eggshell Membrane NEM®is a food-sourced ingredient derived from the membrane of an eggshell. It supplies essential nutrients needed to support joint mobility and the healthy production of cartilage and connective tissue. It is a unique biological matrix proven bioavailable and effective. Double-blind, placebo-controlled and open-label trials have all showcased an increase in joint comfort, flexibility, and increased range of motion. Published human studies have shown beneficial results in 7-10 days.
Glucosamine and Chondroitin
Glucosamine and Chondroitin are the most popular substances and most widely used ingredients in joint health products. Clinical studies are numerous but results are unclear and differ widely. After years of research, it is still difficult to precisely assess their level of efficacy but they no longer appear to be silver bullets as once thought. Nonetheless they can be useful in assisting other active ingredients and help to restore functionality faster. There is also data showing that these mucopolysaccharides support the healing process of injured tendons.
It is important to remember that Chondroitin in its basic form it is mostly useless since it is simply not absorbed. The benefits of Chondroitin Sulfate only concerns the pharmagrade CS, a highly purified and depolymerized substance. Conventional food grade chondroitin is a very large molecule that is not assimilated through the intestinal mucosa. The molecular weight of the Chondroitin used has a direct influence upon its level of efficacy. The properties of the low molecular weight Chondroitin do not apply to conventional Chondroitin (Biol. Pharm. bull. 27(1)47-51 - 2004).
Orthosilicic acid (non-crystalized silica)
Silicon is an essential trace mineral that is naturally present in the human body. It play a major role in bone strength, healthy skin and nails and cartilage formation. Studies have shown that a silicon deficient diet produces aberrant metabolism of the bone and connective tissue leading to structural abnormalities of the articular cartilage with small and poorly formed joints. It was later discovered that silicon deprivation decreases collagen formation in wound healing as well as bone formation.*
Silicon is widely available and abundant in nature but its bioavailability is very poor. It is an extremely unstable compound that crystalizes very quickly forming an insoluble inert substance. Its absorption is drastically low and it can’t be utilized by the human organism.
Hyalgen contains a stable high absorption form of dietary silicon. It is an ortho-silicic acid molecule stabilized in maltodextrin. It is stabilized by a proprietary method that inhibits the polymerization of ortho-silicic acid, keeping the molecule stable and increasing its bioavailability in the body.
- Oesser, S.; Adam, M., Babel, W. and Seifert, J. (1999). "Oral administration of 14C labelled gelatine hydrolysate leads to an accumulation of radioactivity in cartilage of mice (C57/BL)". Journal of nutrition 129 (10): 1891–1895. PMID 10498764
- Oesser, S.; Seifert, J. (2003). "Stimulation of type II collagen biosynthesis and secretion in bovine chondrocytes cultured with degraded collagen". Cell tissue research 311 (3): 393–399. doi:10.1007/s00441-003-0702-8. PMID 12658447
- In-Vivo: A Randomized Double Blind Placebo Clinical Trial Evaluating the Efficacy and Safety of Hyal-Joint® Compared to Placebo for the Improvement of Quality of Life in Adults with Osteoarthritis of the Knee. Kalman et al (2008) Nutrition Journal. 7(3) (http://www.nutritionj.com/content/7/1/3)
- In-Vitro:Comparative efficacy of Hyal-Joint® , extracted hyaluronic acid (HA) and fermented HA on the synthesis of endogenous HA by human synoviocytes. Torrent et al (2009) Osteoarthritis and Cartilage. 17( 1): S278-279.
- In-Vitro:Comparison of the efficacy of two products sold as orally-administered. Hyaluronic acid supplements, Hyal-Joint® and ID386 on the endogenous in-vitro synthesis of hyaluronic acid by human synoviocytes Torrent et al (2009) Osteoarthritis and Cartilage. 17( 1): S277-278.
- In-Vivo: Oral administration of Hyal-Joint® for the treatment of knee OA with synovial effusion. Moller et al (2009). Clinical Nutrition Supplements. 4 (2):171-172.
- In-Vitro: Study on the chondroprotective effects of Hyal-Joint®. Torrent A, Ruhí R, Martínez C, Castells G, de Castellarnau-Castellà C. Anti-inflammatory activity and absorptio of a natural rooster comb extract (Hyal-Joint®). Osteoarthritis and Cartilage, Volume 18, Supplement 2, September 2010, Page S246.
- In-Vitro: Assay to Determine the Intestinal Absorption of Hyal-Joint®. Torrent A, Ruhí R, Martínez C, Castells G, de Castellarnau-Castellà C. Anti-inflammatory activity and absorptio of a natural rooster comb extract (Hyal-Joint®). Osteoarthritis and Cartilage, Volume 18, Supplement 2, September 2010, Page S246.
- In Vivo: Effects of Hyal-Joint® in rats developing type II collagen arthritis. Castillo V, Bendele AM, Li K, Martinez-Puig D, Turner SM, Chetrit C. Effects of oral administration of Hyal-Joint in 17 day rat developing type II collagen arthritis. Osteoarthritis and Cartilage, Volume 18, Supplement 2, September 2010, Page S244.
- Comparison of different experimental designs to evaluate of an intervention in osteoarthritis patients. D. Martinez-Puig, C. Chetrit, I. Möller. Osteoarthritis and Cartilage, Volume 19, Supplement 1, September 2011, Page S147
- In-Vivo: Effects of oral administration of Hyal-Joint for the treatment of knee OA with synovial effusion: A double-blind placebo-controlled study. I. Möller, D. Martinez-Puig, C. Chetrit Osteoarthritis and Cartilage, Volume 19, Supplement 1, September 2011, Page S223
- Baeurle SA, Kiselev MG, Makarova ES, Nogovitsin EA (2009). "Effect of the counterion behavior on the frictional–compressive properties of chondroitin sulfate solutions". Polymer 50 (7): 1805–1813. doi:10.1016/j.polymer.2009.01.066
- Chou MM; Vergnolle N; McDougall JJ; Wallace JL; Marty S; Teskey V; Buret AG Effects of chondroitin and glucosamine sulfate in a dietary bar formulation on inflammation, interleukin-1beta, matrix metalloprotease-9, and cartilage damage in arthritis. Exp Biol Med (Maywood) 2005 Apr;230(4):255-62 ISSN: 1535-3702
- Lippiello L; Woodward J; Karpman R; Hammad TA In vivo chondroprotection and metabolic synergy of glucosamine and chondroitin sulfate. Clin Orthop Relat Res 2000 Dec;(381):229-40 ISSN: 0009-921X
- Baici A; Bradamante P. Interaction between human leukocyte elastase and chondroitin sulfate Chem Biol Interact 1984 Sep 1;51(1):1-11.
- Bartolucci C, Cellai L, Corradini C, Corradini D, Lamba D, Velona I. Chondroprotective action of chondroitin sulfate on the digestion of hyaluronan by bovine testicular hyaluronidase Int J Tissue React 1991;13(6):311-317.
- Jordan KM, Recommendations Arden NK. EULAR (2003). "an evidence based approach to the management of knee osteoarthritis: Report of a Task Force of the Standing Committee for International Clinical Studies Including Therapeutic Trials (ESCISIT)". Ann Rheum Dis 62 (12): 1145–1155. doi:10.1136/ard.2003.011742. PMC 1754382. PMID 14644851.
- Uebelhart D, Thonar EJ, Delmas PD, et al. Effects of oral chondroitin sulfate on the progression of knee osteoarthritis: a pilot study. Osteoarthritis Cartilage 1998;6(Suppl A):39–46.
- Verbruggen G, Goemaere S, Veys EM. Chondroitin sulfate: S/DMOAD (structure/disease modifying anti-osteoarthritis drug) in the treatment of finger joint OA. Osteoarthritis Cartilage 1998;6(Suppl A):37–8.
- Bucsi L, Poór G. Efficacy and tolerability of oral chondroitin sulfate as a symptomatic slow-acting drug for osteoarthritis (SYSADOA) in the treatment of knee osteoarthritis. Osteoarthritis Cartilage 1998;6(Suppl A):31–6.
- Bourgeois P, Chales G, Dehais J, et al. Efficacy and tolerability of chondroitin sulfate 1200 mg/day vs chondroitin sulfate 3X400 mg/day vs placebo. Osteoarthritis Cartilage 1998;6(Suppl A):25–30.
- Pipitone V, Ambanelli U, Cervini C, et al. A multicenter, triple-blind study to evaluate galactosaminoglucuronoglycan sulfate versus placebo in patients with femorotibial gonarthritis. Curr Ther Res 1992;52:608–38.
- Bazières B, Loyau G, Menkès CJ, et al. Le chondroïtine sulfate dans le traitement de la gonarthrose et de la coxarthrose. Rev Rhum Mal Ostéoartic 1992;59:466–72 [in French].
- Conrozier T, Vignon E. Die Wirkung von Chondroitinsulfat bei der Behandlung der Hüft Gelenksarthrose. Eine Doppelblindstudie gegen Placebo. Litera Rheumatologica 1992;14:69–75 [in German].
- L’Hirondel JL. Klinische Doppelblind-Studie mit oral verabreichtem Chondroitinsulfat gegen Placebo bei der tibiofermoralen Gonarthrose (125 Patienten). Litera Rheumatologica 1992;14:77–82 [in German].
- Morreale P, Manopulo R, Galati M, et al. Comparison of the antiinflammatory efficacy of chondroitin sulfate and diclofenac sodium in patients with knee osteoarthritis. J Rheumatol 1996;23:1385–91.
- Leeb BF, Petera P, Neumann K. Results of a multicenter study of chondroitin sulfate (Condrosulf) use in arthroses of the finger, knee and hip joints. Wien Med Wochenschr 1996;146:609–14.
- Analysis of glycosaminoglycans in human serum after oral administration of chondroitin sulfate.Rheumatol Int. 1992;12(3):81-8. Baici A, Hörler D, Moser B, Hofer HO, Fehr K, Wagenhäuser FJ. Department of Rheumatology, University Hospital, Zurich, Switzerland.
- The bioavailability and pharmacokinetics of glucosamine hydrochloride and low molecular weight chondroitin sulfate after single and multiple doses to beagle dogs. Adebowale A, Du J, Liang Z, Leslie JL, Eddington ND. Biopharm Drug Dispos. 2002 Sep;23(6):217-25.
- Effects of low molecular weight chondroitin sulfate on type II collagen-induced arthritis in DBA/1J mice. Cho SY, Sim JS, Jeong CS, Chang SY, Choi DW, Toida T, Kim YS. Biol Pharm Bull. 2004 Jan;27(1):47-51.
- E. M. Carlisle, In vivo requirement for silicon in articular cartilage and connective tissue formation in the chick,J. Nutr. 106, 478–484 (1976).
- E. M. Carlisle, A silicon requirement for normal skull formation in chicks,J. Nutr. 110, 352–359 (1980). https://www.ncbi.nlm.nih.gov/pubmed/1255267?dopt=Abstract
- Formation in Wounds and Bone, and Ornithine Transaminase Enzyme Activity in Liver C. D. Seaborn and F. H. Nielsen March 1, 2002 https://link.springer.com/article/10.1385/BTER:89:3:251
|Subtitle||The specialized supplement to stimulate the renewal metabolism of the joint cartilage|
|In Stock Date||N/A|